Healthy older volunteers were given 5 mg of apixaban twice daily or 20 mg of rivaroxaban daily. Andexanet is designed to reverse the anticoagulant effects of factor Xa inhibitors. The most trusted, influential source of new medical knowledge and clinical best practices in the world.īleeding is a complication of treatment with factor Xa inhibitors, but there are no specific agents for the reversal of the effects of these drugs.
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